SYMPOSIUM
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Thursday 23 and Friday 24 september 2021, in Nantes

LS2N Amphitheater, Lombarderie Campus 
Faculty of Sciences and Technologies, Nantes University

See program & abstracts

Thursday, September 23, 2021

Time Event (+)
08:00 - 08:35 Welcoming participants  
08:35 - 08:45 Welcome Speech - Pr Jacques Lebreton, Université de Nantes  
08:45 - 09:00 Opening allowance - Pr Olivier GRASSET, VP Recherche et science ouverte, Université de Nantes  
09:00 - 09:15 Introduction - Madame SOULTANI VIGNERON Samia, Vice-présidente du Conseil régional des Pays de la Loire  
09:15 - 12:20 SESSION 1 : Chairman - Pr Jacques LEBRETON, Université de Nantes  
09:15 - 10:15 “A Brief History of PPIs” - Dr Philippe ROCHE, Aix-Marseille Université  
10:15 - 10:45 Coffee break  
10:45 - 11:30 RhoA PPI Axe Results - Dr Gervaise LOIRAND, Université de Nantes  
11:30 - 11:55 "Design of antiviral drugs for bronchiolitis virus using a novel therapeutic target" - Silva KHODJOYAN, Doctorante, Université Paris-Saclay  
11:55 - 12:20 Photoactivated ligands for the control of ion channel activity" - Dr Jérôme MONTNACH, Chercheur postdoctoral, Université de Nantes  
12:20 - 13:45 Lunch cocktail  
13:45 - 17:35 SESSION 2 : Chairman - Pr Sylvain COLLET, Université de Nantes  
13:45 - 14:45 "NMR-guided and fragment-based design of protein-protein interaction inhibitors. Application to CK2 kinase" - Dr Isabelle KRIMM, Université Lyon 1  
14:45 - 15:30 BCL-xL PPI Axe Results - Dr Stéphane TELETCHEA, Université de Nantes  
15:30 - 16:00 Coffee break  
16:00 - 16:45 IL-15 PPI Axe Results - Dr Erwan MORTIER, Université de Nantes  
16:45 - 17:10 "Synthesis and Biological assessments for RhoGTPases’ inhibition" - Thomas RIVIERE, Assistant ingénieur, Université de Nantes  
17:10 - 17:35 "Synthesis and Evaluation of Small Molecule Inhibitors of Interleukin (IL)-15: Towards IL-15 vs IL-2 Selectivity" - Jimmy SMADJA, Doctorant, Université de Nantes  

Friday, September 24, 2021

Time Event (+)
08:30 - 12:00 SESSION 3 : Chairman - Pr Jean-Yves LE QUESTEL, Université de Nantes  
08:30 - 09:30 "Structure-guided design of MCL-1 inhibitors” - Pr Jana SOPKOVA-DE OLIVEIRA SANTOS, Université de Caen Normandie  
09:30 - 10:15 Hsp90 PPI Axe Results - Pr Patrice LE PAPE, Université de Nantes  
10:15 - 10:45 Coffee break  
10:45 - 11:10 "Design of anti-fungal agents against Candida albicans using in silico techniques" - Mohammad ASAD, Doctorant, Université de Nantes  
11:10 - 11:35 "Synthesis & evaluation of Bcl-2 family proteins modulating compounds for cancer treatment" - Dr Nicolas GUEDENEY, Chercheur postdoctoral, Université de Rennes 1  
11:35 - 12:00 "Binding of the Cancer-Related TCTP Protein to Mcl- 1/Bcl-xL Requires and Triggers an Order-to-Disorder Transition to Make its BH3 Region Accessible" - Dr Ewen LESCOP, Chercheur, Université Paris-Saclay  
12:00 - 13:30 Lunch cocktail  
13:30 - 16:00 SESSION 4 : Chairman - Dr Arnaud TESSIER, Université de Nantes  
13:30 - 14:30 “Conception of Natural-Inspired Small-Molecule Inhibitors of Bcl-2 Family Proteins” - Dr Fanny ROUSSI, ICSN, Université Paris-Saclay  
14:30 - 15:15 Rad 51 PPI Axe Results - Pr Fabrice FLEURY, UFIP, Université de Nantes  
15:15 - 15:40 "Strengths, weaknesses and bottlenecks in new drug design and validation" - Dr Stéphane TELETCHEA, Université de Nantes  
15:40 - 16:00 Coffee break  
16:00 - 16:30 Closing of the Symposium and award ceremony for the best oral communication  
  
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