See program & abstracts
    			        
  	
	      	
        	
        		
        		   Thursday, September 23, 2021        	    
        	 
         
    	
        	
    	      	
    	        	
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        	          	        			                 08:00 - 08:35
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        	          	    Welcoming participants        	          	 | 
        	          	
        	          		                             
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        	          	        			                 08:35 - 08:45
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        	          	    Welcome Speech - Pr Jacques Lebreton, Université de Nantes        	          	 | 
        	          	
        	          		                             
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        	          	        			                 08:45 - 09:00
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        	          	    Opening allowance - Pr Olivier GRASSET, VP Recherche et science ouverte, Université de Nantes        	          	 | 
        	          	
        	          		                             
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        	          	        			                 09:00 - 09:15
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        	          	    Introduction - Madame SOULTANI VIGNERON Samia, Vice-présidente du Conseil régional des Pays de la Loire        	          	 | 
        	          	
        	          		                             
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        	          	        			                 09:15 - 12:20
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        	          	    SESSION 1 : Chairman - Pr Jacques LEBRETON, Université de Nantes        	          	 | 
        	          	
        	          		                             
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        	          	        			                 09:15 - 10:15
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        	          	    “A Brief History of PPIs”  - Dr Philippe ROCHE, Aix-Marseille Université        	          	 | 
        	          	
        	          		                             
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        	          	        			                 10:15 - 10:45
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        	          	    Coffee break        	          	 | 
        	          	
        	          		                             
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        	          	        			                 10:45 - 11:30
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        	          	    RhoA PPI Axe Results  - Dr Gervaise LOIRAND, Université de Nantes        	          	 | 
        	          	
        	          		                             
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        	          	        			                 11:30 - 11:55
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        	          	    "Design of antiviral drugs for bronchiolitis virus using a novel therapeutic target" - Silva KHODJOYAN, Doctorante, Université Paris-Saclay        	          	 | 
        	          	
        	          		        	          		        
                                                                 
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        	          	        			                 11:55 - 12:20
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        	          	    Photoactivated ligands for the control of ion channel activity" - Dr Jérôme MONTNACH, Chercheur postdoctoral, Université de Nantes        	          	 | 
        	          	
        	          		                             
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        	          	        			                 12:20 - 13:45
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        	          	     Lunch cocktail        	          	 | 
        	          	
        	          		                             
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        	          	        			                 13:45 - 17:35
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        	          	    SESSION 2 : Chairman - Pr Sylvain COLLET, Université de Nantes        	          	 | 
        	          	
        	          		                             
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        	          	        			                 13:45 - 14:45
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        	          	    "NMR-guided and fragment-based design of protein-protein interaction inhibitors. Application to CK2 kinase" - Dr Isabelle KRIMM, Université Lyon 1        	          	 | 
        	          	
        	          		        	          		        
                                                                 
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        	          	        			                 14:45 - 15:30
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        	          	    BCL-xL PPI Axe Results - Dr Stéphane TELETCHEA, Université de Nantes        	          	 | 
        	          	
        	          		                             
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        	          	        			                 15:30 - 16:00
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        	          	    Coffee break        	          	 | 
        	          	
        	          		                             
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        	          	        			                 16:00 - 16:45
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        	          	    IL-15 PPI Axe Results - Dr Erwan MORTIER, Université de Nantes        	          	 | 
        	          	
        	          		                             
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        	          	        			                 16:45 - 17:10
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        	          	    "Synthesis and Biological assessments for RhoGTPases’ inhibition" - Thomas RIVIERE, Assistant ingénieur, Université de Nantes        	          	 | 
        	          	
        	          		        	          		        
                                                                 
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        	          	        			                 17:10 - 17:35
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        	          	    "Synthesis and Evaluation of Small Molecule Inhibitors of Interleukin (IL)-15: Towards IL-15 vs IL-2 Selectivity" - Jimmy SMADJA, Doctorant, Université de Nantes        	          	 | 
        	          	
        	          		        	          		        
                                                                 
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        		   Friday, September 24, 2021        	    
        	 
         
    	
        	
    	      	
    	        	
    	          		| Time | 
    	          		Event | 
    	          		
                                                            
                                    (+)
                                
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        	          	| 
        	          	        			                 08:30 - 12:00
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        	          	    SESSION 3 : Chairman - Pr Jean-Yves LE QUESTEL, Université de Nantes        	          	 | 
        	          	
        	          		                             
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        	          	        			                 08:30 - 09:30
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        	          	    "Structure-guided design of MCL-1 inhibitors” - Pr Jana SOPKOVA-DE OLIVEIRA SANTOS, Université de Caen Normandie        	          	 | 
        	          	
        	          		        	          		        
                                                                 
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        	          	        			                 09:30 - 10:15
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        	          	    Hsp90 PPI Axe Results - Pr Patrice LE PAPE, Université de Nantes        	          	 | 
        	          	
        	          		                             
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        	          	| 
        	          	        			                 10:15 - 10:45
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        	          	    Coffee break        	          	 | 
        	          	
        	          		                             
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        	          	        			                 10:45 - 11:10
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        	          	    "Design of anti-fungal agents against Candida albicans using in silico techniques" - Mohammad ASAD, Doctorant, Université de Nantes        	          	 | 
        	          	
        	          		                             
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        	          	        			                 11:10 - 11:35
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        	          	    "Synthesis & evaluation of Bcl-2 family proteins modulating compounds for cancer treatment" - Dr Nicolas GUEDENEY, Chercheur postdoctoral, Université de Rennes 1        	          	 | 
        	          	
        	          		        	          		        
                                                                 
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        	          	        			                 11:35 - 12:00
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        	          	    "Binding of the Cancer-Related TCTP Protein to Mcl- 1/Bcl-xL Requires and Triggers an Order-to-Disorder Transition to Make its BH3 Region Accessible" - Dr Ewen LESCOP, Chercheur, Université Paris-Saclay        	          	 | 
        	          	
        	          		        	          		        
                                                                 
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        	          	        			                 12:00 - 13:30
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        	          	    Lunch cocktail        	          	 | 
        	          	
        	          		                             
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        	          	        			                 13:30 - 16:00
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        	          	    SESSION 4 : Chairman - Dr Arnaud TESSIER, Université de Nantes        	          	 | 
        	          	
        	          		                             
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        	          	        			                 13:30 - 14:30
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        	          	    “Conception of Natural-Inspired Small-Molecule Inhibitors of Bcl-2 Family Proteins” - Dr Fanny ROUSSI, ICSN, Université Paris-Saclay        	          	 | 
        	          	
        	          		        	          		        
                                                                 
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        	          	        			                 14:30 - 15:15
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        	          	    Rad 51 PPI Axe Results - Pr Fabrice FLEURY, UFIP, Université de Nantes        	          	 | 
        	          	
        	          		                             
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        	          	        			                 15:15 - 15:40
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        	          	    "Strengths, weaknesses and bottlenecks in new drug design and validation" - Dr Stéphane TELETCHEA, Université de Nantes        	          	 | 
        	          	
        	          		        	          		        
                                                                 
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        	          	| 
        	          	        			                 15:40 - 16:00
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        	          	    Coffee break        	          	 | 
        	          	
        	          		                             
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        	          	        			                 16:00 - 16:30
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        	          	    Closing of the Symposium and award ceremony for the best oral communication        	          	 | 
        	          	
        	          		                             
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